Knights claimed $255k veteran defender Dustin Fletcher (leg), $396k midfielder Jason Winderlich (ankle) and $338k club stalwart Andrew Welsh (leg) were close to returning after injuries.
"All will play on Friday night, pending today's (Tuesday's) training session," Knights admitted, including $306k youngster Kyle Reimers who returned in Round 11 after injury.
Knights added, "Fletcher will come in, it's been seven weeks now for Dustin, he's had a good three or four weeks on the training track, so he'll come into the side.
"We're looking to bring Andrew Welsh back in, which has been a marvellous comeback.
"Jason's (Winderlich) first major training session is today – if he gets through he'll come back into the 22."
And in more positive news, the Bombers coach also revealed $214k midfielder Henry Slattery was close to a return but perhaps doubtful for Friday's game after a hamstring problem.
"Slattery would have to really impress me today to come into the team," Knights said.
In other injury news, Essendon also made it known big $222k ruckman Jason Laycock will miss the rest of the season with the foot injury he's been battling.